Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

1 SELECTIVE ACTIVATION OF p 38 MAPK PATHWAY BY SYNTHETIC MONOPHOSPHORYL LIPID

SELECTIVE ACTIVATION OF p38 MAPK PATHWAY BY SYNTHETIC MONOPHOSPHORYL LIPID A 1 Caglar Cekic , Carolyn R. Casella, Chelsea A. Eaves, Atsushi Matsuzawa, Hidenori Ichijo, and Thomas C. Mitchell 2*† From the Department of Microbiology and Immunology and Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, and Laboratory of Cell Signaling, Graduate ...

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway.

The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear. Here we show that, in C(2)C(12) cells, overexpression or suppression of APPL1 enhanced or suppressed, respectively, adiponectin-stimulated p38 MAPK upstream kinase cascade, consisting of transforming growth factor-β-acti...

Activation of the p38 MAPK pathway by follicle-stimulating hormone regulates steroidogenesis in granulosa cells differentially.

In the present study, we started out to test whether the follicle-stimulating hormone (FSH)-activated p38 MAPK signaling cascade was involved in the regulation of steroidogenesis in granulosa cells (GCs). GCs were prepared from the ovaries of DES-treated immature rats and cultured in serum-free medium. Treatment of GCs with FSH (50 ng/ml) induced the phosphorylation of p38 MAPK rapidly with the...

Regulation of p38 MAPK by MAPK Kinases

Increased activation of p38 MAPK in COPD.

Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated protein kinases (MAPKs). Therefore, the aim of the present study was to evaluate the expression of the phosphorylated, active form of p38 MAPK (phospho-p38) in the lungs of COPD patients. Surgical specimens were obtaine...